STREAM is a collaboration of researchers who share a common set of principles about the goals and methods for studying clinical translation. We apply empirical and philosophical tools for addressing scientific, ethical, and policy challenges in the development and translation of health technologies. Our members work in ethics, epidemiology, biology, psychology, and various medical specialties. The network is centered at McGill University, and has affiliates throughout North America and abroad.
London AJ, Kimmelman J. Accelerated Drug Approval and Health Inequality. JAMA Intern Med. 2016. DOI:10.1001/jamainternmed.2016.2534
Mattina J, MacKinnon N, Henderson VC, Fergusson D, Kimmelman J. Design and Reporting of Targeted Anti-Cancer Preclinical Studies: A Meta-Analysis of Animal Studies Investigating Sorafenib Antitumor Efficacy. Cancer Res 2016; DOI: 10.1158/0008-5472.CAN-15-3455 [Epub ahead of print]
Grankvist H and Kimmelman J. How do researchers decide early clinical trials? Medicine, Health Care and Philosophy 2016.
Kimmelman J, Henderson VC. Assessing risk/benefit for trials using preclinical evidence: a proposal. Journal of Medical Ethics 2015; DOI: doi:10.1136/medethics-2015-102882
Carlisle B, Demko N, Freeman G, Hakala A, MacKinnon N, Ramsay T, Hey SP, London AJ, Kimmelman J. Benefit, Risk, and Outcomes in Drug Development: A Systematic Review of Sunitinib JNCI 2015; DOI: 10.1093/jnci/djv292