STREAM is a collaboration of researchers who share a common set of principles about the goals and methods for studying clinical translation. We apply empirical and philosophical tools for addressing scientific, ethical, and policy challenges in the development and translation of health technologies. Our members work in ethics, epidemiology, biology, psychology, and various medical specialties. The network is centered at McGill University, and has affiliates throughout North America and abroad.
Ouimet C, Bouche G, Kimmelman J. Diminishing clinical impact for post-approval cancer clinical trials: A retrospective cohort study. Plos one. 2022 Sep 12.
Hutchinson N, Moyer H, Zarin DA, Kimmelman J. The proportion of randomized controlled trials that inform clinical practice. eLife. 2022 Aug 17.
MacPherson A, Gumnit E, Ouimet C, Hutchinson N, Kieburtz K, Pearson TS, Kimmelman J. Quantifying Patient Investment in Novel Neurological Drug Development. Neurotherapeutics. 2022 Jun 28.
Sheng J, Feldhake E, Zarin DA, Kimmelman J. Completeness of clinical evidence citation in trial protocols: A cross-sectional analysis. Med. 2022 Apr 8.
Kim SY, Kimmelman J. Practical steps to identifying the research risk of pragmatic trials. Clinical Trials. 2022 Mar 29.
Bittlinger M, Bicer S, Peppercorn J, Kimmelman J. Ethical Considerations for Phase I Trials in Oncology. Journal of Clinical Oncology. 2022 Mar 11.
Kane PB, Moyer H, MacPherson A, Papenburg J, Ward BJ, Broomell SB, Kimmleman J. Relationship between lay and expert perceptions of COVID-19 vaccine development timelines in Canada and USA. PloS one. 2022 Feb 15.
Benjamin DM, Hey SP, MacPherson A, Hachem Y, Smith KS, Zhang SX, Wong S, Dolter S, Mandel DR, Kimmelman J. Principal investigators over-optimistically forecast scientific and operational outcomes for clinical trials. PLoS ONE. 2022 Feb 8.
Hutchinson N, Klas K, Carlisle BG, Kimmelman J, Waligora M. How Informative were Early SARS-CoV-2 Treatment and Prevention Trials? A longitudinal cohort analysis of trials registered on clinicaltrials. gov. Plos one. 2022 Jan 21.
Oliviero E, Kourkopoulos G, Kimmelman J. Success rates for US and Canadian anticancer drug development efforts in pediatric oncology. Pediatric Blood & Cancer. 2022 Jan 14.
Jonathan Kimmelman quoted by Science News about the lack of reproducibility of pre-clinical cancer biology research.
Jonathan Kimmelman quoted by The Globe and Mail about the affordability and regulation of regenerative medicine.
Jonathan Kimmelman quoted by Science about poor quality science and how it contributes to misinformation in the media.
Jonathan Kimmelman quoted by STAT about social responsibility of medical practitioners.
Jonathan Kimmelman quoted by FiveThirtyEight about use of Ivermectin as a COVID-19 treatment.
Jonathan Kimmelman quoted by The Dallas Morning News about the testing of a new Covid-19 remedy backed by little evidence.
Jonathan Kimmelman quoted by Science about the use of Botox to ease depression.
Jonathan Kimmelman quoted by Fortune about the dangers of FDA emergency use authorizations.
Jonathan Kimmelman interviewed by The ASOS Press about important ethical considerations before launching a clinical cancer trials.
Jonathan Kimmelman quoted by Axios about the credibility of the AstraZeneca vaccine.
Jonathan Kimmelman quoted by The Harvard Crimson about reproducibility in science.
Jonathan Kimmelman quoted by CBC's Radio Canada about the impact of scientific papers published on pre-print servers.
Jonathan Kimmelman quoted in The National Post about Canada's decision to deviate from the dose schedules validated in clinical trials for COVID-19 vaccine administration.
Jonathan Kimmelman quoted in La Presse about the ethics of placebo-controlled clinical trials for approved COVID-19 vaccines.