STREAM is a collaboration of researchers who share a common set of principles about the goals and methods for studying clinical translation. We apply empirical and philosophical tools for addressing scientific, ethical, and policy challenges in the development and translation of health technologies. Our members work in ethics, epidemiology, biology, psychology, and various medical specialties. The network is centered at McGill University, and has affiliates throughout North America and abroad.
STREAM is inviting applications for a postdoctoral research fellow (PDF). The position requires a background a background in clinical trials or ethics. The project will examine how risk, benefit, burdens, and clinical hypotheses evolve as new drugs are developed- and whether there are ways to improve efficiencies in clinical development. The project will also apply forecast methods.
Jonathan Kimmelman quoted in STAT News: "Tiny human brain organoids implanted into rodents, triggering ethical concerns"
Jonathan Kimmelman quoted in Health News Review: "In need of scrutiny: Misleading stem cell claims by academic medical centers"
Jonathan Kimmelman quoted in MIT Technology Review: "Artificial Human Embryos Are Coming, and No One Knows How to Handle Them"
Jonathan Kimmelman quoted in Reuters Health: "Discrepancy between trial goals, results may mask treatment risks"
Kimmelman J, Carlisle B, Gönen M. Drug Development at the Portfolio Level Is Important for Policy, Care Decisions and Human Protections. JAMA. August 2017. DOI:10.1001/jama.2017.11502
Benjamin D, Mandel D, Kimmelman J. Can cancer researchers accurately judge whether preclinical reports will reproduce? PLOS Biology June 29, 2017.
Hakala A, Fergusson D, Kimmelman J. Nonpublication of trial results for new neurological drugs: A systematic review. Annals of Neurology, 2017.
Kimmelman J, Resnik DB, Peppercorn J, Ratain MJ. Burdensome Research Procedures in Trials: Why Less is More. JNCI. 2017. DOI:https://doi.org/10.1093/jnci/djw315
Mattina J, Carlisle B, Hachem Y, Fergusson D, Kimmelman J. Inefficiencies and Patient Burdens in the Development of the Targeted Cancer Drug Sorafenib: A Systematic Review. PLOS Biology February 3, 2017.