What is STREAM?

STREAM is a collaboration of researchers who share a common set of principles about the goals and methods for studying clinical translation. We apply empirical and philosophical tools for addressing scientific, ethical, and policy challenges in the development and translation of health technologies. Our members work in ethics, epidemiology, biology, psychology, and various medical specialties. The network is centered at McGill University, and has affiliates throughout North America and abroad.

Our Latest Publications

Kane PB, Benjamin DM, Barker RA, Lang AE, Sherer T, & Kimmelman J. Forecasts for the Attainment of Major Research Milestones in Parkinson’s Disease. Journal of Parkinson’s Disease, Apr 24, 2020.

Our Latest Publications

Zhang SX, Fergusson D, Kimmelman J. Proportion of Patients in Phase 1 Oncology Trials Receiving Treatments that are Ultimately ApprovedJournal of the National Cancer Institute. April 1, 2020.

Press coverage:

A New Look at the Dose-Response Relationship in Phase 1 Oncology Trials, Cancer Therapy Advisor, May 13, 2020.

Our Latest Publications

Carlisle BG, Doussau A, Kimmelman J. Patient burden and clinical advances associated with postapproval monotherapy cancer drug trials: a retrospective cohort studyBMJ Open. February 17, 2020.

Our Latest Publications

Federico C, Mogil JS, Ramsay T, Fergusson DA, Kimmelman J. A systematic review and meta-analysis of pregabalin preclinical studiesPain. January 22, 2020.

Our Latest Publications

Hutchinson N, Vinarov E, Iasonos A, Kimmelman J. Ethical and Policy Issues for Seamless Phase I Oncology TrialsJournal of Clinical Oncology. December 26, 2019.

Our Latest Publications

Feustel AC, MacPherson A, Fergusson DA, Kieburtz K, Kimmelman J. Risks and benefits of unapproved, disease-modifying treatments for neurodegenerative disease. Neurology. December 2, 2019.

Published commentary:

Rezak M, de Carvalho M. Disease modification in neurodegenerative diseases: Not quite there yetNeurology. December 2, 2019.

Our Latest Publications

Sarvas H, Carlisle B, Dolter S, Vinarov E, Kimmelman J. Impact of Precision Medicine on Efficiencies of Novel Drug Development in CancerJournal of the National Cancer Institute. November 13, 2019.

Our Latest Publications

Carlisle BG, Zheng T, Kimmelman J. Imatinib and the long tail of targeted drug developmentNature Reviews Clinical Oncology. October 24, 2019.

Our Latest Publications

Doussau A, Vinarov E, Barsanti-Innes B, Kimmelman J. Comparison between protocols and publications for prognostic and predictive cancer biomarker studiesClinical Trials. October 5, 2019.

Our Latest Publications

Carlisle BG, Doussau A, Kimmelman J. Benefit, burden, and impact for a cohort of post-approval cancer combination trialsClinical Trials. October 3, 2019.

Our Latest Publications

Kimmelman J. Phase I trials as therapeutic options: (usually) a betrayal of evidence-based medicineNature Reviews Clinical Oncology. August 30, 2019.

Our Latest Publications

London AJ, Kimmelman J. Clinical Trial Portfolios: A Critical Oversight in Human Research Ethics, Drug Regulation, and Policy. Hastings Center Report. August 20, 2019.

Press coverage:

In Hunting for Cures, Ethics Can Strengthen Clinical TrialsCarnegie Mellon News. November 6, 2019.

Our Latest Publications

MacPherson A, Kimmelman J. Ethical development of stem-cell-based interventions. Nature Medicine. July 3, 2019.

News

Jonathan Kimmelman quoted in STAT News on the ethical questions surrounding patient funding of clinical trials.

Cancer Therapy Advisor covers research published by Jonathan Kimmelman and student Sean Zhang on the proportion of patients in Phase 1 oncology trials that receive treatments that are ultimately approved.

Jonathan Kimmelman quoted in La Presse on the ethical issues with challenge studies for testing COVID-19 interventions.

Jonathan Kimmelman quoted in Wired on the costs of making treatment decisions based on preliminary findings.

Radio Canada, Scientific American, Le Devoir, El Mundo, Der Spiegel, Dagens Nyheter, and The Washington Post cover research published by Jonathan Kimmelman and collaborator Alex John London in Science on the scientific standards for pandemic research.

Jonathan Kimmelman appears on CBC The National and is quoted in CBC on the changing scientific and ethical standards in the context of COVID-19 vaccine development.

Jonathan Kimmelman quoted in Dallas News on the inconclusive evidence around experimental COVID-19 interventions.

Jonathan Kimmelman quoted in Clinical Research News on the distinction between research and care in the context of the WHO's malaria vaccine implementation programme.

Jonathan Kimmelman quoted in Vox on the ethical obligation to practice social distancing during the COVID-19 pandemic.

Jonathan Kimmelman quoted in STAT News on a first-in-human trial of an experimental COVID-19 vaccine without prior animal testing.

Jonathan Kimmelman quoted in BMJ on the ethics of the WHO's malaria vaccine study.

Jonathan Kimmelman quoted in Bloomberg on the selection of drugs and combinations for clinical testing in cancer patients.

Carnegie Mellon News covers research published by Jonathan Kimmelman and collaborator Alex John London on the ethics of clinical trial portfolios.

Jonathan Kimmelman quoted in Nature on placebo-controlled clinical trials for regenerative medicine in an article on Japan's regulation of cell-based interventions.

Jonathan Kimmelman quoted in Neurology Today on the risks and benefits of Alzheimer's prevention trials.

Jonathan Kimmelman quoted in Nature on the use of registries for preclinical trials.

Jonathan Kimmelman quoted in Chemistry World on the hype surrounding unproven stem-cell based interventions.

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