What is STREAM?

STREAM is a collaboration of researchers who share a common set of principles about the goals and methods for studying clinical translation. We apply empirical and philosophical tools for addressing scientific, ethical, and policy challenges in the development and translation of health technologies. Our members work in ethics, epidemiology, biology, psychology, and various medical specialties. The network is centered at McGill University, and has affiliates throughout North America and abroad.

Our Latest Publications

MacPherson A and Kimmelman J. Ethical development of stem-cell-based interventions. Nature Medicine. July 3, 2019.

Our Latest Publications

Pratte M, Ganeshamoorthy S, Carlisle B, Kimmelman J. How well are Phase 2 cancer trial publications supported by preclinical efficacy evidence? International Journal of Cancer. May 14, 2019.

Our Latest Publications

Federico C, Wang T, Doussau A, Mogil J, Fergusson D, Kimmelman J. Assessment of Pregabalin Postapproval Trials and the Suggestion of Efficacy for New Indications: A Systematic Review. JAMA Internal Medicine. January 1, 2019.

Press coverage:

When Clinical Trials Are Marketing Ploys, Not Science. Forbes. November 28, 2018.

Unconfirmed exploratory trials after approvals may cause too much off-label prescribing. STAT News. December 12, 2018.

Our Latest Publications

Kimmelman J, Waligora M, Lynch HF. Participant Protection in Phase 1 Pediatric Cancer Trials. JAMA Pediatrics. November 12, 2018.

Our Latest Publications

Kimmelman J. Better to be in The Placebo Arm for Trials of Neurological Therapies?. Cell Transplantation. June 1, 2018.

Our Latest Publications

Kimmelman J, Tannock, I. The paradox of precision medicine. Nature Reviews Clinical Oncology. April 19, 2018.

Our Latest Publications

London A, Kimmelman J. Clinical Trials in Medical Center Advertising. JAMA Oncology. April 5, 2018.

Companion opinion piece: Cancer centers sell out science when they advertise clinical trials as treatment. STAT News. April 25, 2018.

News

Jonathan Kimmelman quoted in Bloomberg on the ethics of genetic medicine.

Jonathan Kimmelman quoted in STAT News on a study of a diagnostic cancer test published with missing data.

Jonathan Kimmelman quoted in Nature on the recent gene-edited baby scandal and the new Chinese regulations being implemented as a consequence.

STAT News and Forbes cover research published by doctoral candidate Carole Federico and Jonathan Kimmelman on how post-approval exploratory trials can influence off-label prescribing.

Jonathan Kimmelman interviewed on CTV's Your Morning on Monday and quoted in CBC Second Opinion on a recent study revealing the requests scientists make to statisticians to fudge data.

Jonathan Kimmelman interviewed by Radio Canada about a controversial pediatric cancer study conducted at Montreal's Ste-Justine Hospital.

Jonathan Kimmelman quoted in NPR: All Things Considered, on medical researchers' ability to make predictions about study outcomes.

Jonathan Kimmelman quoted in Dallas News, on the drawbacks of patient-funded clinical trials.

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