Forecast Leaderboard

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PROJECT: Forecasting Reproducibility of Preclinical Cancer Studies

SYNOPSIS: Experts and novices gave subject probability forecasts of preclinical cancer replication studies conducted by the Reproducibility Project: Cancer Biology.

Read the paper here.

See the project page here and more background here.

For more information on how to interpret the results and other FAQs, click here.

Experts: Survey 1

Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs (Sugahara),
Discovery and preclinical validation of drug indications using compendia of public gene expression data (Sirota),
Melanoma genome sequencing reveals frequent PREX2 mutations (Berger)

RankBrier scoreNameInstitution
10.000Gerd PfeiferBeckman Research Institute (City of Hope)
20.004Alex MackenzieChildren’s Hospital of Eastern Ontario/University of Ottawa
30.023[Consent withheld][Consent withheld]

Group median: 0.31; 95% C.I. [0.26,0.36]

Experts: Survey 2

BET bromodomain inhibition as a therapeutic strategy to target c-Myc (Delmore),
Inhibition of BET recruitement to chromatin as an effective treatment for MLL-fusion leukaemia (Dawnson),
The CD47-signal regulatory preotein alpha (SIRPa) interaction is a therapeutic target for human solid tumors (Willingham)

RankBrier scoreNameInstitution
10.042David BryderLund University
20.071Sourav BandyopadhyayUCSF
30.076Kornelia PolyakDana-Farber Cancer Institute

Group median: 0.40; 95% C.I. [0.35,0.44]

Novices: Survey 1

Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs (Sugahara),
Discovery and preclinical validation of drug indications using compendia of public gene expression data (Sirota),
Melanoma genome sequencing reveals frequent PREX2 mutations (Berger)

RankBrier scoreName
10.052Ruth Franklin
20.104Taylor Sells
30.111[Consent withheld]

Group median: 0.32; 95% C.I. [0.26,0.37]

 

Do you think you can beat these experts? Write us at forecasting@translationalethics.com or daniel.benjamin2@mail.mcgill.ca to see what other forecasting competitions we are running.

Scores are published with individual forecaster approval.
Contact us at any time if you would like your name removed from our leaderboard.

BibTeX

@Manual{stream2017-1302,
    title = {Forecast Leaderboard},
    journal = {STREAM research},
    author = {STREAM admin},
    address = {Montreal, Canada},
    date = 2017,
    month = may,
    day = 31,
    url = {http://www.translationalethics.com/forecast-scoreboard/}
}

MLA

STREAM admin. "Forecast Leaderboard" Web blog post. STREAM research. 31 May 2017. Web. 21 Jul 2017. <http://www.translationalethics.com/forecast-scoreboard/>

APA

STREAM admin. (2017, May 31). Forecast Leaderboard [Web log post]. Retrieved from http://www.translationalethics.com/forecast-scoreboard/


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