Members

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Photo Credit: Rob Streiffer

Photo Credit: Rob Streiffer

Kimmelman received the 2006 Maud Menten New Investigator Prize (Institute of Genetics), a CIHR New Investigator Salary Award (2008), and a Friedrich Bessel- Humboldt Fellowship (2014).  He has been a commentator in numerous media outlets, including the New York Times, Globe and Mail, and BBC World Service.  He also has served in an advisory capacity for the World Medical Association, FDA, and the Canadian Institute of Health Research.  Kimmelman formerly chaired the ethics and public policy committee of the International Society of Stem Cell Research, where he led revisions of the society’s ethics guidelines for stem cell research and clinical translation. He has served as a member on three National Academy of Medicine Committees – including one advising NASA on Health Standards for Long Duration and Exploration Spaceflights. He is a deputy editor at Clinical Trials, and an associate editor at PLoS Biology.

When not writing grants or responding to referee comments, Kimmelman can be found wandering through industrial ruins, or listening to contemporary classical music.

You can follow Jonathan on Twitter: @kimmelmanj


Adelaide Doussau

Adelaide Doussau

Adelaide Doussau is a postdoctoral research fellow holding an M.D. with a specialization in Public Health and Epidemiology, and Ph.D. in Public Health, specialized in Clinical Trials Methodology and Biostatistics. Her dissertation focused on phase I dose-finding methodology of cancer clinical trials (Curie Institute, Paris and Bordeaux School of Public Health (ISPED), France).
She worked as a fellow/assistant professor in the Clinical Trial Unit of Bordeaux University Hospital and Bordeaux School of Public Health, and completed a postdoctoral fellowship in the Department of Bioethics of the National Institutes of Health (NIH).
Her research interests are concentrated on the ethics of biomedical research, especially in the design, conduct, analysis and reporting of clinical trials or epidemiologic studies. She recently focused her research on stepped-wedge design for experimental vaccines in the setting of Ebola outbreak, and on placebo-controlled cancer clinical trials.


Daniel Benjamin

Danny Benjamin

Dr. Benjamin is postdoctoral fellow in the Biomedical Ethics Unit working on forecasting the success of translation studies via expert judgments. He recently earned his PhD in Psychometrics and Quantitative Psychology at Fordham University. Dr. Benjamin’s dissertation examined the joint impacts of conflict and imprecision from multiple forecasts on people’s estimation and judgements, and he received a National Science Foundation (NSF) Dissertation Research Grant to develop this research. His master’s research examined the effects of experience on giving and receiving advice. Previously, Daniel studied psychology and mathematics at the University of North Carolina. His research interests include topics in judgment and decision-making focusing on 1) the communication of uncertain and ambiguous information, especially in partisan domains, 2) forecasting and elicitation of expert judgments, and 3) behavioral methodology. Danny looks forward to exploring all of Montreal’s diverse cuisines with his young children.


Benjamin Carlisle

Benjamin Carlisle

Benjamin “Murph” Carlisle

Benjamin Carlisle earned his MA in bioethics from McGill University. His MA thesis was a critique of phase IV drug studies, and he is now a doctoral candidate in the Department of Experimental Medicine and the Rabinowitch Fellow for Biomedical Ethics at McGill. Prior to coming to McGill, he studied philosophy at the University of Western Ontario. Currently, he is researching the risk and benefit to patient-subjects in clinical trials of both successful and unsuccessful anticancer drugs in the context of potential threats to the medical information economy. Murph’s side-interests include cryptography, virtue ethics and Lojban.


Nadine Demko

Nadia Demko

Nadia Demko recently graduated with her B.Sc. in Neuroscience at McGill and has begun her M.Sc. in Experimental Medicine with the STREAM group. Her undergraduate thesis focused on the electrophysiological and pharmacological properties of AMPA-type ionotropic receptors. Having gained experience in pharmacology research, Nadia became interested in the translation process of therapeutics and began work with Dr. Kimmelman in her undergrad. Currently, her Master’s research focuses on the extent to which preclinical studies address various threats to valid clinical inference and ultimately, how preclinical study designs affect clinical outcomes. When not immersed in academics, Nadia very much enjoys playing piano and singing, long jogs on Mont Royal, and exploring her St. Henri neighbourhood.


Carole Federico

Carole Federico

Carole Federico

Carole Federico, BSc, MSc, is a doctoral student in Experimental Medicine under the supervision of Jonathan Kimmelman. Carole’s research focuses on ethical, social, and evidentiary aspects of drug development, with particular attention given to pain research. Her work is funded by a PhD Studentship in Pain Research from The Louise and Alan Edwards Foundation. In her free time, Carole enjoys reading, studying French and psychoanalyzing her adopted cat, Felix.

 
 


Amanda Hakala

Amanda Hakala

Amanda Hakala is a Master’s student in Experimental Medicine studying under Dr. Jonathan Kimmelman. Her master’s thesis is assessing the concordance of preclinical and clinical results in the literature for Parkinson’s and epilepsy drugs that have reached Phase III clinical testing. Amanda jumped at the chance to join the STREAM team as an undergraduate after hearing Dr. Kimmelman lecture in her Neuroethics course. She recently completed a project assessing publication bias in trials of untranslated drugs. Amanda received her B.Sc. in Neuroscience from McGill in June 2014. Her undergraduate thesis assessed the effect of exercise on Purkinje cell dendrites in the mouse cerebellum. When not enthusiastically working, Amanda loves to study Spanish, take architectural photographs and dance salsa. She is currently working her way through the Wheel of Time series.


Gaëlle Le Moine

Gaëlle Le Moine

Gaëlle Le Moine is a research trainee, working under the supervision of Dr. Jonathan Kimmelman for a 6-month internship. She is pursuing a Master’s degree in Public Health, with a specialty in Comparative Effectiveness Research, at Paris Descartes University in France. In 2016 she obtained a Master’s degree in Sciences and Technologies for Health, from Bordeaux University; during that time, she had the opportunity to work on clinical projects management as an apprentice for two years. This experience led her to want to learn more about ethical issues in Clinical Research, more specifically in oncology. Currently, her research project focuses on the risk, benefit and burden associated with participation in clinical trials studying VEGF-inhibition in breast cancer, and also on citation bias in clinical reports. Gaëlle does not like clichés, but as a Frenchie she loves cheese and red wine. During her free time, Gaëlle enjoys running, meeting new people and discovering Canadian landscapes.


Holly Sarvas

Holly Sarvas

Holly is a Master’s student in Experimental Medicine – Bioethics under the supervision of Dr. Kimmelman. Holly earned her BScN at Laurentian University in 2016 and is a Registered Nurse within the province of Ontario. Her interest in oncology led her to STREAM to see how oncological research can ultimately impact the clinical realm. Holly’s master’s thesis assesses the ethics and policy surrounding precision medicine drug development strategies, with a particular emphasis on novel trial designs such as basket trials, umbrella trials, and platform designs. In her spare time, Holly enjoys exploring the many tasteful and tasty restaurants in Montreal, and getting a little too competitive in intramural activities.


Esther Vinarov

Esther Vinarov

Esther recently graduated from McGill with a BA&Sc in Cognitive Science. As an undergrad she did research for a digital humanities lab, where she worked on projects involving text analysis, citation networks, and publication trends in humanities journals. Like other STREAM members, she was heavily influenced by a neuroethics course, which solidified her interest in research, ethics, health policy and law. She is currently getting involved with several projects, including a study comparing investigators’ and independent experts’ forecasts on the outcomes of clinical trials. Esther enjoys listening to too many podcasts and managing her goldendoodle’s journey to snapchat celebrity status.


Tiger Zheng

Tiger Zheng

Tiger Zheng received his B.A. in Philosophy from McGill in 2016. His honours thesis explored the relationship between contemporary virtue ethics in the context of environmentalism within a richness axiological framework. His current project explores the developmental trajectories of Imatinib, Dasatinib, and Nilotinib, and the extent to which drug developers build on prior trial evidence in related drugs. Outside of research ethics, his research interests lie primarily in neo-Aristotelian virtue ethics, and, in particular, the implicit interpretive and evaluative aspects of virtue instantiation. He devotes what little spare time he has left to attempting to play music and completing an ever-growing reading list.


Undergraduate research assistants

 

Sylviya Ganeshamoorthy

Sylviya is a U3 Neuroscience major. She is currently working through extractions and helping on the citations project.

Kara Smith

Kara is a U2 Cognitive Science major. She is working mainly on the predictions project.

Aden Feustel

Aden is a U2 Honours Neuroscience major. He is primarily working on a cross-sectional study of clinical trials.

Sandy Wong

Sandy is a U2 Honours Neuroscience major, and Computer Science minor. She is primarily working on a cross-sectional study of clinical trials.

Michael Pratte

Michael Pratte is a Neuroscience Major and Classical Studies Minor student. He is currently working mainly on the preclinical citations project.

Sean Zhang

Sean is graduating with a Neuroscience Major. He is currently working on leukemia and angiogenesis extractions, as well as forecasting.


Affiliates

Peter Grabitz

Peter Grabitz

Peter Grabitz is currently finishing medical school at Charité University Berlin in Germany. His work at STREAM analyses reasons why paradigms in clinical research persist – even though evidence suggests otherwise. Peter currently focuses on citation networks in cancer drug development and wants to develop different and new ways of visualizing relations between scientific publications. He likes to rethink established structures in research wherever possible. Be aware: If you ask him about where to publish research, you may very well end up in an emotional discussion about access to knowledge. Surprisingly, he believes table tennis players are respected sportsmen (because he is one himself) and loves to do Origami.


Spencer Hey

Spencer Hey

Spencer Phillips Hey

Dr. Hey was a founding member of STREAM and a resident member from 2012-2015. He is now a research fellow in the Department of Medicine’s Division of Pharmacoepidemiology and Pharmacoeconomics at the Brigham and Women’s Hospital and a faculty member at the Harvard Center for Bioethics in Boston, Massachusetts. He received his PhD in philosophy from the University of Western Ontario and his BA (Hons) in philosophy from University of Illinois at Chicago. For the most up-to-date information about his work, see his personal web page.

 


Alumni

Brianna Barsanti-Innes

Brianna Barsanti-Innes

Brianna Barsanti-Innes completed her B.Sc. majoring in Neuroscience at McGill. In her final year her research project looked at the fMRI resting state network differences between adolescents with or without a predisposition for future substance abuse. Brianna developed an interest for biomedical ethics after taking a neuroethics course as part of the program. Brianna’s most recent project at STREAM looked at the accumulation of evidence and changes in research practices over time as cancer biomarkers are identified and translated into clinical practice. Brianna is now attending medical school at the University of Toronto, and when not studying, can be found listening to country music and trying to incorporate hot sauce into just about any cuisine.


Georgina Freeman

Georgina Freeman

Georgina Freeman

Georgina Freeman completed her Master’s in Bioethics at McGill and she enjoyed it so much that she decided to stay and work as a Research Assistant at STREAM. Her project looked at characterizing the co-development of cancer diagnostics and drugs. Articles based on her thesis work have been published in Clinical Cancer Research and British Journal of Cancer. Gina is now a Research Associate with the Ward of the 21st Century (W21C.org) in the Department of Medicine at the University of Calgary, evaluating Alberta Health Services‘ Strategic Clinical Networks (SCNs).

 


Hannah Grankvist

Hannah Grankvist

Hannah Grankvist

Dr. Grankvist was a postdoctoral fellow from the Department of Thematic Studies – Technology and Social Change at Linköping University in Sweden. She received her PhD in Technology and Social Change in 2011 from Linköping University. Her research interests are found in areas such as STS and medicine, ethical, social and policy dimensions of translational research, bioethics and research ethics. Currently, Dr. Grankvist is a research fellow at the Department of Thematic Studies – Technology and Social change at Linköping University. Her research focuses on how various stakeholders negotiate uncertainties surrounding initiation and design of phase 1 trials of novel therapeutics, in order to increase knowledge about decision-making in translational medical research.


Yasmina Hachem

Yasmina was an undergraduate research assistant who graduated from McGill with a degree in Anatomy and Cell Biology. At STREAM, she worked mostly on the predictions project, and she is currently attending medical school.


Valerie Henderson

Valerie Henderson

Valerie Henderson

Valerie Henderson completed her M.Sc. in Biochemistry at McGill’s Goodman Cancer Research Centre before joining Dr. Kimmelman’s research team in January 2012. Valerie worked to develop methods for the systematic review and meta-analysis of data from preclinical experiments in animal models of cancer. Her research with Dr. Kimmelman focused on how preclinical design and experimental practices can influence the decision to move into clinical trials during drug development. Articles stemming from this work have been published in PLoS Medicine , eLife , and the Journal of Medical Ethics . Valerie is currently completing a medical degree at McGill and expects to graduate in 2018.


Nathalie Mackinnon

Nathalie is a recent graduate of the McGill Neuroscience Program. She worked on the preclinical extractions project and pursued a study examining recruitment outcomes in trials.


Vince I Madai

Vince I Madai

Vince I. Madai is currently a postdoctoral researcher at Charité Medical University in Berlin, Germany. He finished his medical studies in 2008 and completed his M.D. thesis (“Dr. med”) spending countless nights staring into the electron microscope searching for labeled cells. He then transitioned from imaging cells to imaging human brains- more precisely human stroke brains. Working full time as a postdoctoral researcher at the “Centre for Stroke Research Berlin” in group of Prof. Jan Sobesky, Vince also entered the Ph.D. program “Medical Neuroscience” at Charité in 2012 working on new angiography methods at 7 Tesla Ultrahigh Field MRI in cerebrovascular disease. Vince´s interest in bioethics was sparked by the M.A. program “Medical Ethics” at the University of Mainz, Germany, which was specifically designed for health professionals. He met Dr. Kimmelman in 2015 during his sabbatical in Berlin and since, has been working on his M.A. thesis with Dr. Kimmelman about replication (or better non-replication) in preclinical stroke research. In his free time he learns guitar and Hebrew, and is proud to have read all fantasy novels which are worth reading.


James Mattina

James Mattina

James Mattina graduated from the Honours Neuroscience Program at McGill. His undergraduate research project investigated the role of neurofilament misassembly in the pathogenic cascade of neurodegenerative diseases, namely amyotrophic lateral sclerosis (ALS). His most recent project at STREAM was working on the clinical and preclinical extraction projects with a focus on the cancer drug, sorafenib. The preclinical project evaluates the relationship between preclinical study design and clinical outcomes, while the clinical project assesses patient burden across the trajectory of drug development. James is now attending medical school at McGill, and in his free time enjoys playing volleyball, painting, and putting a socially unacceptable amount of sugar in his tea.


Taiji Wang

Taiji Wang

Taiji Wang received her B.Sc. from McGill, majoring in Neuroscience and minoring in Music.  Her undergraduate thesis investigated the propensity for long-term potentiation in epileptic compared to normal mouse brain cortex. Taiji’s research focused on quantifying the comparative risks and benefits encountered by trial participants in the clinical development of abandoned cancer drugs versus standard of care. In her free time, Taiji enjoys hiking, long runs, playing classical piano, and making yummy desserts.

 


BibTeX

@Manual{stream2013-24,
    title = {Members},
    journal = {STREAM research},
    author = {STREAM admin},
    address = {Montreal, Canada},
    date = 2013,
    month = may,
    day = 8,
    url = {http://www.translationalethics.com/members/}
}

MLA

STREAM admin. "Members" Web blog post. STREAM research. 08 May 2013. Web. 24 Jun 2017. <http://www.translationalethics.com/members/>

APA

STREAM admin. (2013, May 08). Members [Web log post]. Retrieved from http://www.translationalethics.com/members/


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