Filing Cabinet Syndrome: The Effect of Nonpublication of Preclinical Research

Much has already been said about Filing Cabinet syndrome in medical research: the tendency of researchers to publish exciting results from clinical trials, and to stash null or negative findings safely away from public view in a filing cabinet. Nonpublication distorts the medical literature, because it prevents medical practitioners from accessing negative information about drugs.… Continue reading Filing Cabinet Syndrome: The Effect of Nonpublication of Preclinical Research

STAIRing at Method in Preclinical Studies

Medical research, we all know, is highly prone to bias. Researchers are, after all, human in their tendencies to mix desire with assessment. So too are trial participants. Since the late 1950s, epidemiologists have introduced a number of practices to clinical research designed to reduce or eliminate sources of bias, including randomization of patients, masking… Continue reading STAIRing at Method in Preclinical Studies