In the November 29, 2008 issue of Lancet, two reports (plus a commentary) report the famously disappointing outcome of a recent placebo-controlled study testing adenoviral vector-based vaccines against HIV. News reports over a year ago reported that the study was halted after an interim analysis failed to show any prospect of proving effective. More troubling, subgroup analysis suggested that vaccine recipients who had high pre-existing immunity to the adenoviral vectors showed higher rates of sero-conversion compared with placebo. As this vaccine was among the most promising and advanced in terms of development, these results were seen as a major setback.
BibTeX
@Manual{stream2009-110, title = {Found Figures: Picking up the Pieces after an HIV Vaccine Trial Fails}, journal = {STREAM research}, author = {Jonathan Kimmelman}, address = {Montreal, Canada}, date = 2009, month = feb, day = 3, url = {http://www.translationalethics.com/2009/02/03/found-figures-picking-up-the-pieces-after-an-hiv-vaccine-trial-fails/} }
MLA
Jonathan Kimmelman. "Found Figures: Picking up the Pieces after an HIV Vaccine Trial Fails" Web blog post. STREAM research. 03 Feb 2009. Web. 01 Sep 2024. <http://www.translationalethics.com/2009/02/03/found-figures-picking-up-the-pieces-after-an-hiv-vaccine-trial-fails/>
APA
Jonathan Kimmelman. (2009, Feb 03). Found Figures: Picking up the Pieces after an HIV Vaccine Trial Fails [Web log post]. Retrieved from http://www.translationalethics.com/2009/02/03/found-figures-picking-up-the-pieces-after-an-hiv-vaccine-trial-fails/