The Scope of this Blog

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Though my primary focus is on gene transfer, I will occasionally wander into other areas of translational pharmaceutical research, including cell transfer (also sometimes called “cell therapy”), monoclonal antibodies, small-molecule drugs that target novel biological mechanisms, or large-molecule drugs.


These types of translational clinical research raise a similar cluster of issues– namely, high degrees of uncertainty, risk, scientific complexity, desperately ill volunteers, ambitious investigators, financial interests, and complicated intellectual property issues.

BibTeX

@Manual{stream2008-184,
    title = {The Scope of this Blog},
    journal = {STREAM research},
    author = {Jonathan Kimmelman},
    address = {Montreal, Canada},
    date = 2008,
    month = feb,
    day = 14,
    url = {http://www.translationalethics.com/2008/02/14/the-scope-of-this-blog/}
}

MLA

Jonathan Kimmelman. "The Scope of this Blog" Web blog post. STREAM research. 14 Feb 2008. Web. 17 Oct 2019. <http://www.translationalethics.com/2008/02/14/the-scope-of-this-blog/>

APA

Jonathan Kimmelman. (2008, Feb 14). The Scope of this Blog [Web log post]. Retrieved from http://www.translationalethics.com/2008/02/14/the-scope-of-this-blog/


Introduction to Lost in Translation

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Within the past six months, a fifth patient developed a lympho-proliferative disorder in an X-SCID gene transfer trial.  The RAC has all but cleared AAV vector as a causal agent in the death of Jolee Mohr in a rheumatoid arthritis study.  A Merck HIV-vaccine trial involving adenoviral vectors was terminated after a data safety monitoring board found that volunteers receiving placebo had lower rates of sero-conversion.


I created this blog to establish a forum to report and comment on developments in gene transfer—and other areas of translational clinical research— that raise interesting or important ethical questions.  The first several posts will contain some introductory material that provides definitions and describes the scope of this blog.

BibTeX

@Manual{stream2008-187,
    title = {Introduction to Lost in Translation},
    journal = {STREAM research},
    author = {Jonathan Kimmelman},
    address = {Montreal, Canada},
    date = 2008,
    month = feb,
    day = 6,
    url = {http://www.translationalethics.com/2008/02/06/introduction-to-lost-in-translation/}
}

MLA

Jonathan Kimmelman. "Introduction to Lost in Translation" Web blog post. STREAM research. 06 Feb 2008. Web. 17 Oct 2019. <http://www.translationalethics.com/2008/02/06/introduction-to-lost-in-translation/>

APA

Jonathan Kimmelman. (2008, Feb 06). Introduction to Lost in Translation [Web log post]. Retrieved from http://www.translationalethics.com/2008/02/06/introduction-to-lost-in-translation/


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